Solving the P0300 Code Enigma A Troubleshooting Guide for Engine Performance

I have been battling the dreaded P0300: Random Multiple Misfire Detected. So far I have replaced plug and ignition coils, and the intake and exhaust solenoids. The check engine light came on which turned out to be a P0300 code (Random/Multiple Cylinder Misfire Detected) The car runs fine. After an intermittent engine light (every 3-4 weeks) and reading a P0300 Random misfire / multiple cylinders and also a occasional rough idle, I tuned it up. The inspection facility determined the codes; Diagnostic Trouble Codes (DTC) P0300 through P0306 - Cylinders 1-6 Misfire detected as well as ... The P0300 code is a general system misfire, something that effects all cylinders as opposed to a single specific cylinder and as such the culprit is some that ... A P0300 OBD DTC code indicates a random or multiple misfire. If the last digit is a number other than zero, it corresponds to the cylinder ... A P0300 trouble code means that one or more cylinders is misfiring and not completely burning its fuel/air mixture. Bearing in mind that you ... A misfire code P0301, for example, would indicate a misfire problem in cylinder #1. Of course, misfires can be caused by a lot of things. It ... 0300 is misfire. You changed the plugs. Bad plug, damaged plug wire (yanked off by wire and not boot), cracked plug, not connected at coil. 2008. Altima 3.5 L engine. Currently has OBD trouble code P0300, which is defined as Random Cylinder Misfire......where to start?